Shortly after the story begins, the Red Suns, a highly experienced racing team from Mount Akagi led by Ryosuke Takahashi, challenge the local Speed Stars team to a set of races on Mount Akina. Dispirited after watching the Red Suns' superior performance during a practice run, the Speed Stars expect to lose. Later that night, the Red Suns' #2 driver, Keisuke Takahashi, heading home after the last practice run, is defeated soundly by a mysterious Sprinter Trueno, despite driving a much more powerful Mazda RX-7 (FD3S). An investigation into the identity of the driver leads to Bunta Fujiwara, Takumi's father. While trying to do his best for the team on Mount Akina, Iketani suffers a crash and damages his car and injures himself. He is unable to take part in the race to represent his team. Iketani begs Bunta to help the Speed Stars defeat the Red Suns, and he initially refuses, later relenting to \"maybe\" show up at the race. At the same time, Takumi asks Bunta if he can borrow the car for a day to take a trip to the beach with a potential girlfriend (Natsuki Mogi), and Bunta seizes the moment by granting permission (plus a full tank of fuel) on the condition that Takumi defeats Keisuke. On the night of the race, the Trueno does not show up, and the Speed Stars enlist a backup driver (Kenji) for the first run. At the last moment before the race starts, the AE86 arrives. Takumi steps out of the car to the bewilderment of the Speed Stars, who were expecting Bunta. He easily defeats Keisuke by utilizing a dangerous \"gutter run\" technique (putting both the left/right tires into the gutters to prevent centrifugal force pushing the car outward) on the mountain road's hairpin corners.
In 1998, Initial D was adapted into an animated television series produced by OB Planning and Prime Direction. The first episode premièred on Fuji TV on April 8, 1998. The initial series ran for 26 weekly episodes with the finale airing on December 5, 1998.
Eight years after the release of \"Fourth Stage\" in 2004, Animax aired \"Initial D Fifth Stage\". Animax has aired the series on a pay-per-view basis on SKY PerfecTV!'s Perfect Choice Premier 1 channel. The first two episodes aired on November 9, 2012. The rest of the episodes were broadcast two per month till May 10, 2013.
In 2014, \"Initial D Final Stage\" became the latest installment in the anime series. Animax has aired its first two episodes on a pay-per-view basis on its own brand new ANIMAX PLUS channel, on May 16, 2014, on its new subscription VOD (Video On Demand) service, which allows subscribers to watch all the latest anime series. Initial D Final Stage will start right after where Fifth Stage left off. There are a total of four episodes that makes up this mini stage. The final two episodes were broadcast on June 22, 2014.
Marilyn most recently served as Chief People Officer for Anaplan, where she helped scale the company through several growth stages, including a successful initial public offering. She brings to Netskope more than 20 years of experience in high-visibility HR and talent acquisition roles, including for Alfresco, Quotient Technology, AECOM, BMC Software, and Cisco Systems.
Results: There was large variability in the accumulation of numbers of clinical malaria episodes experienced by the children, despite being of similar age and living in the same general location. One group of children from a particular sub-region of the cohort stopped accumulating clinical malaria episodes earlier than other children in the study. Despite lack of further clinical episodes of malaria, these children had higher asymptomatic parasite densities and higher antibody titres to a panel of P. falciparum blood-stage antigens.
( a) The fitted monotonic increasing functions to cumulative malaria episodes against age for all children (grey) who left the study at 15 years of age, with the mean fitted line (black) to all children. ( b) The first derivative of the fitted monotonic functions in ( a), considered as the number of episodes each child experiences in a year.
By the age of 8, 2 out of 56 children do not go on to experience any further clinical malaria episode over the entire study period. This value increases to 22 out of 56 by age 12. Generally, there does not seem to be any discernible trend in terms of cumulative number of episodes for the 38 children who experienced an episode within the last three years of the study ( Figure 2a, c). Of the 22 children who stop experiencing episodes before the last three years, the rate at which they accumulated episodes slowed after an initial peak, but this peak varied for each child ( Figure 2b, d). There does not seem to be a specific age where children as a whole suddenly acquire episodes. However, children who plateaued in their accumulation of clinical malaria episodes did not experience more than 9 episodes.
The fitted monotonic increasing functions to cumulative malaria episodes against age for children who experienced a malaria episode between the age of 13 and 15 in blue ( a) and plateaued in their episodes at the age of 12 in red ( b). The first derivative of the fitted monotonic functions of children who experienced a malaria episode between the age of 13 and 15 in blue ( c) and plateaued in their episodes at the age of 12 in red ( d).
This manuscript studies the acquisition of clinical episodes of malaria over 10 years and identifies two patterns; one where children stop acquiring further clinical episodes after age 12 and one where they continue to acquire them. They relate this to both asymptomatic parasite densities and anti-malarial antibody responses. The data availability is fantastic and very clear with the additional files outlining the variable information and the script used for analyses. The manuscript is generally well-written but could use further clarification on the points below (in addition to points made by the first reviewer).
Based on the eligibility criteria, an electronic screening tool will be created and piloted. During the first stage of the screening process, two independent reviewers (VD and AG) will assess titles and abstracts against the eligibility criteria. In an event of disagreement, reviewers will first attempt to resolve through discussion. If no consensus can be reached, a third reviewer (DF) will mediate the process. After the first screening process, full-text records will be obtained for potentially eligible studies. The full text screening will be conducted by two reviewers (VD and AG). During both stages of the screening process the agreement between the two reviewers will be assessed using the kappa statistic. The PRISMA flow diagram will used to summarise the study selection process.47
VD and DF are responsible for the conception of the research question, development of the protocol and initial drafting of the manuscript. DF is lead supervisor of VD and ABR and NRH are co-supervisors. All supervisors have provided guidance on methodological decisions and proposed analyses. VD and AG will be the first and second reviewer. DF will be the third reviewer. All authors will contribute to data interpretation, conclusions and dissemination. All authors have read and subsequently approved the final manuscript. DF is the guarantor of the review. 781b155fdc